The End of Alzheimer’s: The First Program to Prevent and Reverse Cognitive Decline: Dale Bredesen

A groundbreaking plan to prevent and reverse Alzheimer’s Disease that fundamentally changes how we understand cognitive decline.

Everyone knows someone who has survived cancer, but until now no one knows anyone who has survived Alzheimer’s Disease.



on August 22, 2017
Format: Hardcover

As an editor for a major health site I was able to carefully read the End of Alzheimer’s long before its publication date. I read about 200 books a year and this was clearly one of the top three I have read this year. Dr. Bredeson is a rare physician that has escaped the confines of conventional medicine and explored strategies that really do radically reduce the risk of Alzheimer’s and improve those that already have the condition. In my view he is the leading Alzheimer’s expert in the world today and I am grateful he has taken the time out of his busy career to present information that can radically change the course of Alzheimer’s.

Why is this an important issue? Because we have a tsunami of Alzheimer’s disease approaching on and it is on track to take the lives of 45 million of the 325 million Americans alive today. It’s currently the third leading cause of death in the US and is costing the United States over $220 billion annually. It is a trillion-dollar global health problem. It was the sixth leading cause of death

Dr. Bredesen is uniquely qualified to write this book as he has spent most of his three decades as a physician in this field and was trained at Cal Tech and Johns Hopkins. He is the director of Neurodegenerative Disease Research at the University of California, Los Angeles (UCLA) School of Medicine, He has identified a number of molecular mechanisms at work in this disease, and has created a novel program to treat and reverse it that he calls ReCODE (Reversal of Cognitive Decline)

Many are concerned about this disease and have had themselves tested for the genetic risk factor Apolipoprotein E epsilon 4 (ApoE4). An estimated 75 million Americans have the single allele for ApoE4. Those who are ApoE4 positive have a 30 percent lifetime risk of developing the disease. Approximately 7 million have two copies of the gene, which puts them at a 50 percent lifetime risk.

One of the highlights of the book is his strategy of how to actually reverse ApoE4 damage. This can be done by simply implementing intermittent fasting and restricting your eating window to 4-8 hours a day. This is because ApoE4 appears to be a gene that all ancient humans had and it provided an metabolic advantage for those that were regularly going without food and fasting for periods as was common in ancient times. Individuals that had this gene would actually live longer as they could more easily switch between fat and carb burning. This knowledge can help you actually reverse the damage that most of us acquire when we inherit this gene by merely implementing intermittent fasting.

His ReCode program discussed three dozen different tests that one can screen for and if they are abnormal they can be addressed to improve the synaptic balance to a more healthy level and reverse or radically reduce the risk of Alzheimer’s. If you ever had any concern about Alzheimer’s there is no question in my mind that this is the book to get. Strongly recommended.